Immediately following mTBI, there are several metabolic, hemodynamic, stru … Pain Med. Traumatic Brain Injury (TBI) is an injury to the brain caused by a trauma to the head (head injury). 2013.3:23https://doi.org/10.1186/2110-5820-3-23. Traumatic brain injury (TBI) is physical injury to brain tissue that temporarily or permanently impairs brain function. Definition Traumatic brain injury is a non degenerative, non congenital insult to the brain from an external mechanical force ,possibly leading to permanent or temporary impairment of cognitive, physical and psychosocial functions, with an associated diminished or altered state of consciousness 3. Secondary brain injury occurs at a time after the initial mechanical trauma. While public health initiatives such as seatbelts and airbags have had a major impact, it will be impossible to prevent traumatic brain injury.Therefore, it is important that we understand the pathophysiology of secondary brain injury to be able to effectively treat our patient and also to develop novel targets of future interventions. Reference 2 3. Elevation of the head during intensive care management in people with severe traumatic brain injury. Incidence increased in children